胃癌的肠型和弥漫型：1951年以来瑞典的长期趋势。
Intestinal and diffuse types of gastric cancer: secular trends in Sweden since 1951.
作者信息
Lundegårdh G, Lindgren A, Rohul A, Nyrén O, Hansson L E, Bergström R, Adami H O
机构信息
Department of Surgery, University Hospital, Uppsala, Sweden.
出版信息
Br J Cancer. 1991 Dec;64(6):1182-6. doi: 10.1038/bjc.1991.487.
In order to test the hypothesis that the general decline in gastric cancer observed in many countries is due to a selective decline in Laurén's intestinal type, we re-examined all 427 histologic sections obtained from gastric carcinomas diagnosed at the Department of Pathology, University Hospital, Uppsala, Sweden, in 1951, 1961, 1971-72 and 1981. The relative proportions of intestinal and diffuse type cancers were compared. The intestinal type was significantly (P less than 0.001) more common among elderly people than in the younger age groups. The relative proportions of intestinal type carcinoma in the four periods under study were 65%, 55%, 42% and 60%, respectively. The absence of any clearly discernible trend over time contradicts the hypothesis of diverse secular trends for intestinal and diffuse types of gastric carcinoma.
为了检验许多国家胃癌总体发病率下降是由于劳伦氏肠型胃癌选择性下降这一假设，我们重新检查了1951年、1961年、1971 - 1972年以及1981年在瑞典乌普萨拉大学医院病理科诊断的所有427例胃癌组织切片。比较了肠型和弥漫型癌症的相对比例。肠型癌在老年人中比在年轻人群体中显著更常见（P小于0.001）。在研究的四个时期中，肠型癌的相对比例分别为65%、55%、42%和60%。随着时间推移未出现任何明显可辨别的趋势，这与肠型和弥漫型胃癌存在不同长期趋势的假设相矛盾。
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