[艾灸对糖尿病性勃起功能障碍大鼠勃起功能及NO-cGMP通路的影响]

[Effects of moxibustion on erectile function and NO-cGMP pathway in diabetic rats with erectile dysfunction].

作者信息

Yang Yun-kuan, Rong Hai-bo, Chen Hong-pei, Tang Yong

机构信息

College of Acupunctutre & Massage, Chengdu University of TCM, Sichuan 610075, China.

出版信息

Zhongguo Zhen Jiu. 2007 May;27(5):353-6.

PMID:17645258

Abstract

OBJECTIVE

To explore the effect and the mechanism of moxibustion for treatment of diabetic erectile dysfunction (ED).

METHODS

Diabetes mellitus (DM) rat model was induced by streptozotozin (STZ) and then penis erectile experiment of apomorphine (APO) was used to select diabetic ED rats model, which were divided into 2 groups: a model group and a moxibustion group, with another normal control group set up. The moxibustion group were treated with moxibustion at "Shenshu" (BL 23) and "Sanyinjiao" (SP 6) with small moxa cone about the size of a wheat grain. The effects on penis erectile, blood sugar and total NOS, cNOS, iNOS, and cGMP were investigated.

RESULTS

Moxibustion had a certain improving action on blood sugar, improved significantly erectile function, and more significantly increased NOS, cNOS, iNOS activities and cGMP contents in the penis.

CONCLUSION

Moxibustion has a certain action on the erectile function in the diabetic ED rats, which is related with improvement of blood sugar and promoting NO-cGMP pathway.

摘要

目的

探讨艾灸治疗糖尿病性勃起功能障碍（ED）的效果及机制。

方法

采用链脲佐菌素（STZ）诱导糖尿病（DM）大鼠模型，然后用阿扑吗啡（APO）阴茎勃起实验筛选糖尿病性ED大鼠模型，将其分为2组：模型组和艾灸组，另设正常对照组。艾灸组用麦粒大小的小艾炷艾灸“肾俞”（BL 23）和“三阴交”（SP 6）。观察对阴茎勃起、血糖以及总一氧化氮合酶（NOS）、内皮型NOS（cNOS）、诱导型NOS（iNOS）和环磷酸鸟苷（cGMP）的影响。