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一种基于供体激发光诱导电子转移的硫醇反应性荧光探针：邻位取代的关键作用

A thiol-reactive fluorescence probe based on donor-excited photoinduced electron transfer: key role of ortho substitution.

作者信息

Matsumoto Takuya, Urano Yasuteru, Shoda Takuji, Kojima Hirotatsu, Nagano Tetsuo

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033 Japan.

出版信息

Org Lett. 2007 Aug 16;9(17):3375-7. doi: 10.1021/ol071352e. Epub 2007 Jul 24.

DOI:10.1021/ol071352e
PMID:17645349
Abstract

We designed and synthesized a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore. The fluorescence of this probe is strongly quenched by donor-excited photoinduced electron transfer (d-PeT) from BODIPY to maleimide, but after reaction with thiol, the fluorescence of BODIPY is restored, affording a 350-fold intensity increase.

摘要

我们设计并合成了一种基于BODIPY荧光团的新型硫醇反应性荧光探针。该探针的荧光通过从BODIPY到马来酰亚胺的供体激发光诱导电子转移（d-PeT）而强烈猝灭，但在与硫醇反应后，BODIPY的荧光恢复，强度增加了350倍。

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