Li You-Ming, Du Juan, Zhang Hong, Yu Chao-Hui
Department of Gastroenterology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
J Gastroenterol Hepatol. 2008 Feb;23(2):283-9. doi: 10.1111/j.1440-1746.2007.05045.x. Epub 2007 Jul 20.
To elucidate the epidemiology of gastroesophageal reflux disease (GERD) symptoms in outpatients from the Department of Medicine in 10 hospitals in Zhejiang Province, east China.
A cross-sectional survey in the cluster random sample was conducted from November 2004 to June 2005 using a validated Chinese version of the reflux disease questionnaire and other items recording the demographic characteristics for GERD symptoms. The statistical analysis was performed with SPSS 13.0 programs.
A total of 15,283 outpatients from the Department of Medicine were investigated. The prevalence of GERD symptoms was 7.28% (95% confidence interval [CI], 6.87%, and 7.69%) with the prevalence rate increasing with age (P < 0.001), which was higher in men (7.79%, 95% CI: 7.20%, 8.38%) than in women (6.73%, 95% CI: 6.18%, 7.28%; chi2 = 5.81, P < 0.05). The prevalence rate of the gastrointestinal symptoms in GERD symptoms, including epigastric discomfort, nausea, retrosternal pain, belching, globus sensation, loss of appetite, excessive salivation, vomiting, wheezing cough, weight loss, and dysphagia were all higher than the non-GERD patients (P < 0.0001). In the GERD patients, the prevalence of diseases, such as pharyngolaryngitis, snoring, bronchitis, liver disease, and gallbladder disease were all higher than the non-GERD patients (P < 0.01). The multiple logistic regression analysis showed that old age, night-shift work, heavy work burdens, single or divorced people, increase intake of greasy or sweet foods, excessive eating, and constipation were independent risk factors associated with GERD symptoms.
GERD has a high prevalence in China and its main associated factors include respiratory, laryngopharyngeal and dental disorders, sex, anthropometrical variables, and social-psychological characteristics.
阐明中国东部浙江省10家医院内科门诊患者胃食管反流病（GERD）症状的流行病学情况。
2004年11月至2005年6月，采用经过验证的中文版反流病问卷及其他记录GERD症状人口统计学特征的项目，对整群随机样本进行横断面调查。使用SPSS 13.0软件进行统计分析。
共调查了15283名内科门诊患者。GERD症状的患病率为7.28%（95%置信区间[CI]，6.87%和7.69%），患病率随年龄增加而升高（P<0.001），男性患病率（7.79%，95%CI：7.20%，8.38%）高于女性（6.73%，95%CI：6.18%，7.28%；χ2=5.81，P<0.05）。GERD症状中胃肠道症状的患病率，包括上腹部不适、恶心、胸骨后疼痛、嗳气、咽部异物感、食欲不振、流涎过多、呕吐、喘息性咳嗽、体重减轻和吞咽困难，均高于非GERD患者（P<0.0001）。在GERD患者中，咽炎、打鼾、支气管炎、肝病和胆囊疾病等疾病的患病率均高于非GERD患者（P<0.01）。多因素logistic回归分析显示，高龄、夜班工作、工作负担重、单身或离异人群、油腻或甜食摄入量增加、暴饮暴食和便秘是与GERD症状相关的独立危险因素。
GERD在中国患病率较高，其主要相关因素包括呼吸、咽喉和牙齿疾病、性别、人体测量变量以及社会心理特征。
