3-氨基苯甲酰胺对N-亚硝基双（2-氧代丙基）胺诱导叙利亚仓鼠胰腺癌发生起始后阶段的影响。

Effects of 3-aminobenzamide on the post-initiation phase of N-nitrosobis(2-oxopropyl)amine induced pancreatic carcinogenesis in Syrian hamsters.

作者信息

Tsujiuchi T, Mizumoto K, Tsutsumi M, Denda A, Amanuma T, Kondoh S, Konishi Y

机构信息

Department of Oncological Pathology, Cancer Center, Nara Medical College, Japan.

出版信息

Cancer Lett. 1991 Dec 9;61(1):61-6. doi: 10.1016/0304-3835(91)90077-u.

DOI:10.1016/0304-3835(91)90077-u

PMID:1764698

Abstract

Effects of 3-aminobenzamide (ABA) on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxopropyl)amine (BOP) were investigated in Syrian hamsters. Animals were given BOP at a dose of 70 mg/kg body weight by subcutaneous injection and following a 2-week recovery period, were administered basal diet or basal diet containing 0.5, 0.75 and 1.5% ABA for 30 weeks. While the incidences of resultant pancreatic lesions, including hyperplasia, atypical hyperplasia and carcinoma, induced by BOP were not significantly influenced by ABA treatment, the mean numbers of those pancreatic lesions were significantly decreased in a dose-dependent way. The results therefore suggested the possible involvement of poly(ADP-ribosyl)ation in the post-initiation phase of pancreatic carcinogenesis in hamsters.

摘要

在叙利亚仓鼠中研究了3-氨基苯甲酰胺（ABA）对N-亚硝基双（2-氧代丙基）胺（BOP）引发后胰腺癌发生的影响。动物通过皮下注射给予剂量为70mg/kg体重的BOP，在2周的恢复期后，给予基础饮食或含有0.5%、0.75%和1.5%ABA的基础饮食30周。虽然BOP诱导的包括增生、非典型增生和癌在内的胰腺病变的发生率没有受到ABA处理的显著影响，但这些胰腺病变的平均数量以剂量依赖的方式显著减少。因此，结果表明聚（ADP-核糖基）化可能参与了仓鼠胰腺癌发生起始后的阶段。