2型单纯疱疹病毒的宿主范围温度敏感突变体。
Host range temperature-sensitive mutants of herpes simplex virus type 2.
作者信息
Westmoreland D, Rapp F
出版信息
J Virol. 1976 Apr;18(1):92-102. doi: 10.1128/JVI.18.1.92-102.1976.
Abstract
Two small-plaque mutants of herpes simplex virus type 2 (HSV-2) (strain 333), whose growth at 39 C was blocked in certain cell types (cell-dependent temperature sensitivity), were compared compared with parental virus in a number of biological assays. One mutant (no. 69) was found to produce a large number of morphologically normal, but noninfectious, particles; under nonpermissive conditions, these mutant particles were able to interfere with the replication of wild-type HSV-2. The other mutant (no. 74), which is known to belong to a different complementation group, appeared to direct little virus DNA synthesis, even at the permissive temperature. Progeny production and virus DNA synthesis in cells infected by mutant 74 were delayed in comparison with wild-type virus-infected cells. Both mutants were found to be more sensitive to UV irradiation than the parental virus; this was especially marked in the case of mutant 74. Moreover, this mutant was found to have a high transforming efficiency at much lower doses of irradiation than those needed to abolish the cytopathic effect of wildtype HSV-2.
摘要
对两株2型单纯疱疹病毒（HSV - 2）（333株）的小噬斑突变体进行了多项生物学检测，并与亲代病毒进行比较。这两株突变体在39℃下于某些细胞类型中的生长受阻（细胞依赖性温度敏感性）。发现其中一个突变体（69号）产生大量形态正常但无感染性的颗粒；在非允许条件下，这些突变体颗粒能够干扰野生型HSV - 2的复制。另一个突变体（74号）已知属于不同的互补组，即使在允许温度下，其病毒DNA合成似乎也很少。与野生型病毒感染的细胞相比，74号突变体感染的细胞中后代产生和病毒DNA合成均延迟。发现这两个突变体对紫外线照射比亲代病毒更敏感；74号突变体尤其明显。此外，发现该突变体在比消除野生型HSV - 2细胞病变效应所需剂量低得多的照射剂量下具有高转化效率。
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