Wolf H J, Schmidt W, Drenckhahn D
Institut für Histologie und Embryologie, Universität Innsbruck, Austria.
Cell Tissue Res. 1991 Nov;266(2):385-9. doi: 10.1007/BF00318194.
The amniotic epithelium constitutes a diffusion barrier controlling the passage of solutes and water between the amniotic cavity and maternal circulation. With the present immunocytochemical approach, we have shown that several major components of the cyto-skeleton, i.e., actin, alpha-actinin, spectrin and ezrin, are preferentially associated with the apical and lateral cell surfaces of the human amniotic epithelium. Keratins are distributed throughout the entire cytoplasm, whereas vimentin mainly forms a perinuclear scaffold. These findings indicate a role of the various components of the cytoskeleton in the structural integrity and modulation of cell shape and junctional permeability.
羊膜上皮构成了一个扩散屏障，控制着溶质和水在羊膜腔与母体循环之间的通过。通过目前的免疫细胞化学方法，我们已经表明，细胞骨架的几个主要成分，即肌动蛋白、α-辅肌动蛋白、血影蛋白和埃兹蛋白，优先与人羊膜上皮的顶端和侧面细胞表面相关联。角蛋白分布于整个细胞质中，而波形蛋白主要形成核周支架。这些发现表明细胞骨架的各种成分在细胞结构完整性、细胞形状调节和连接通透性方面发挥作用。
