Boyd Jessica H, Macklin Eric A, Strunk Robert C, DeBaun Michael R
Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St. Louis, MO 63108, USA.
Haematologica. 2007 Aug;92(8):1115-8. doi: 10.3324/haematol.11213.
An analysis of a prospective cohort of individuals with sickle cell anemia (SCA), enrolled from birth through adulthood, was conducted to determine if asthma is a risk factor for death in SCA. All-cause mortality was determined for participants after adjusting for known risk factors for death in SCA. The study included 1,963 individuals who were followed for 18,495 patient-years. After controlling for established risk factors, individuals with SCA and asthma had a more than two-fold higher risk of mortality (hazard ratio 2.36, 95% CI 1.21 to 4.62, p=0.01). To summarize, asthma is a risk factor for death in SCA.
对一组从出生到成年的镰状细胞贫血（SCA）患者进行前瞻性队列分析，以确定哮喘是否为SCA患者死亡的危险因素。在对SCA患者已知的死亡危险因素进行校正后，确定了所有参与者的全因死亡率。该研究纳入了1963名个体，随访时间为18495人年。在控制了既定的危险因素后，患有SCA和哮喘的个体死亡风险高出两倍多（风险比2.36，95%置信区间1.21至4.62，p=0.01）。总之，哮喘是SCA患者死亡的危险因素。
