Bafunyembaka Gabriel, Nacher Mathieu, Maniassom Chimène, Birindwa Archippe Muhandule, Elenga Narcisse
Department of Pediatrics, "Franck Joly" Hospital, Western French Guiana, Saint-Laurent du Maroni 97320, French Guiana.
Department of Pediatrics, Bukavu General Reference Hospital, GR4X+2VW Bukavu, Democratic Republic of the Congo.
Children (Basel). 2024 Dec 19;11(12):1541. doi: 10.3390/children11121541.
The overall incidence of asthma in children with sickle cell disease in French Guiana is unknown. Asthma is common in children with sickle cell disease and is associated with increased morbidity and mortality. This study aimed to describe the impact of asthma on the occurrence of acute chest syndrome in children with sickle cell disease who were followed up in French Guiana. We performed a multicenter nested case-control study between January 2012 and December 2022. Our study population consisted of children, aged between 6 months and 18 years, who were diagnosed with sickle cell disease at birth and hospitalized at least once for acute chest syndrome during the study period. A total of 588 children were followed up for sickle cell disease. Of these, 390 had sickle cell disease, 180 had SC, and 18 had Sβ + thalassemia. Of the 390-sickle cell disease, we identified 35 who also had asthma, giving an estimated prevalence of asthma of 8.9% among children with sickle cell disease in French Guiana. Only asthma was significantly associated with acute chest syndrome ( < 0.001). The prevalence of asthma in children with sickle cell disease is underestimated. Asthma is an independent risk factor for acute chest syndrome. Given the seriousness of asthma in children with sickle cell disease, systematic screening for asthma in children with sickle cell disease has been implemented. This screening, which will be evaluated after one year, will help to better characterize asthmatic children with sickle cell disease and improve their care.
法属圭亚那镰状细胞病患儿哮喘的总体发病率尚不清楚。哮喘在镰状细胞病患儿中很常见，且与发病率和死亡率增加相关。本研究旨在描述哮喘对在法属圭亚那接受随访的镰状细胞病患儿急性胸综合征发生情况的影响。我们在2012年1月至2022年12月期间进行了一项多中心巢式病例对照研究。我们的研究人群包括年龄在6个月至18岁之间、出生时被诊断为镰状细胞病且在研究期间因急性胸综合征至少住院一次的儿童。共有588名儿童因镰状细胞病接受随访。其中，390人患有镰状细胞病，180人患有血红蛋白SC病，18人患有Sβ+地中海贫血。在390名镰状细胞病患儿中，我们确定有35人同时患有哮喘，据估计法属圭亚那镰状细胞病患儿中哮喘的患病率为8.9%。只有哮喘与急性胸综合征显著相关（<0.001）。镰状细胞病患儿哮喘的患病率被低估。哮喘是急性胸综合征的独立危险因素。鉴于镰状细胞病患儿哮喘的严重性，已对镰状细胞病患儿实施了哮喘系统筛查。这项筛查将在一年后进行评估，这将有助于更好地描述患有哮喘的镰状细胞病患儿的特征并改善对他们的治疗。
