Selberg O, Schlaak S, Balks H J, von zur Mühlen A, Müller M J
Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Federal Republic of Germany.
Eur J Appl Physiol Occup Physiol. 1991;63(6):417-23. doi: 10.1007/BF00868072.
The contribution of insulin (3.6 pmol.kg body mass-1.min-1) to adrenaline-induced (0.164 nmol.kg fat free mass-1.min-1) thermogenesis was studied in ten postabsorptive healthy volunteers using two sequential protocols. Variables considered were oxygen consumption as well as carbon dioxide production, heart rate, blood pressure, plasma concentrations of glucose, insulin, glycerol, free fatty acids, beta-HO-butyrate and lactate. Adrenaline increased plasma concentrations of glucose, glycerol, free fatty acids, and beta-HO-butyrate, and heart rate and metabolic rate during normo-insulinaemia [61.3 (SEM 6.6) pmol.l-1]. Similar effects were observed during hyperinsulinaemia [167.9 (SEM 18.7) pmol.l-1], but the effect of adrenaline on oxygen consumption was reduced. On average, metabolic rate increased by 12.9% during normo-insulinaemia and by 8.9% during hyperinsulinaemia. We concluded that relative hyperinsulinaemia resulted in decreased adrenaline-induced thermogenesis and therefore increased whole body anabolism.
采用两个连续方案，在10名空腹状态下的健康志愿者中研究了胰岛素（3.6皮摩尔·千克体重⁻¹·分钟⁻¹）对肾上腺素诱导（0.164纳摩尔·千克去脂体重⁻¹·分钟⁻¹）产热的贡献。所考虑的变量包括耗氧量、二氧化碳产生量、心率、血压、血浆葡萄糖、胰岛素、甘油、游离脂肪酸、β-羟基丁酸和乳酸的浓度。在正常胰岛素血症[61.3（标准误6.6）皮摩尔·升⁻¹]期间，肾上腺素增加了血浆葡萄糖、甘油、游离脂肪酸和β-羟基丁酸的浓度，以及心率和代谢率。在高胰岛素血症[167.9（标准误18.7）皮摩尔·升⁻¹]期间也观察到了类似的效应，但肾上腺素对耗氧量的影响有所降低。正常胰岛素血症期间代谢率平均增加12.9%，高胰岛素血症期间增加8.9%。我们得出结论，相对高胰岛素血症导致肾上腺素诱导的产热减少，从而增加了全身合成代谢。
