Plotnikov M B, Chernysheva G A, Smol'iakova V I, Golubeva I V
Eksp Klin Farmakol. 2007 May-Jun;70(3):50-2.
Effect of the intravenous injection of polyosm (30% solution of polyethylene oxide with a molecular mass of 400, PEO-400) was investigated on Wistar rats with a model of brain edema induced by a freezing lesion in one cerebral hemisphere. The brain edema development was estimated by measuring the active resistance of tissues in the right and left parietal cortex and the content of water in both hemispheres. A course of the intravenous injections of polyosm (1 g/kg of PEO-400 daily during 3 days) after the model lesion onset decreased the initially elevated active resistance in the edematous cerebral tissue and reduced water accumulation in the damaged hemisphere.
研究了静脉注射聚渗透剂（分子量为400的30%聚环氧乙烷溶液，PEO - 400）对一侧大脑半球冷冻损伤诱导的脑水肿Wistar大鼠模型的影响。通过测量左右顶叶皮质组织的有效电阻以及两个半球的含水量来评估脑水肿的发展。在模型损伤发生后进行一个疗程的聚渗透剂静脉注射（连续3天每天注射1 g/kg的PEO - 400），可降低水肿脑组织中最初升高的有效电阻，并减少受损半球的水分积聚。
