Viola Antonella, Bronte Vincenzo
Venetian Institute of Molecular Medicine, Padua, Italy; Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy.
Semin Cancer Biol. 2007 Aug;17(4):309-16. doi: 10.1016/j.semcancer.2007.06.005. Epub 2007 Jun 23.
During progression, tumors become refractory to the offensive weapons of the immune system. It has been known for a long time that the tumor microenvironment presents a profound modification in the metabolism of arachidonic acid and amino acids such as l-triptophan and l-arginine. However, only in the last decade we have started to appreciate how these changes might cause dysfunctions in cells of both adaptive and innate immune system. The knowledge of these complex and partially interconnected metabolic pathways is offering new targets for an integrated pharmacological approach aiming at freeing tumor-specific T lymphocytes from the latches of cancer influence.
在肿瘤进展过程中，肿瘤会对免疫系统的攻击武器产生抗性。长期以来，人们已经知道肿瘤微环境在花生四烯酸和诸如L-色氨酸、L-精氨酸等氨基酸的代谢方面呈现出深刻的变化。然而，直到最近十年，我们才开始认识到这些变化可能如何导致适应性和先天性免疫系统细胞功能失调。对这些复杂且部分相互关联的代谢途径的了解，为一种综合药理学方法提供了新的靶点，该方法旨在使肿瘤特异性T淋巴细胞摆脱癌症影响的束缚。
