Hood Donald C, Anderson Susan C, Wall Michael, Kardon Randy H
Department of Psychology, Columbia University, New York, New York 10027, USA.
Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3662-8. doi: 10.1167/iovs.06-1401.
To evaluate a linear model that relates the glaucomatous loss in retinal nerve fiber (RNFL) thickness, measured with optical coherence tomography (OCT), to the loss in sensitivity, measured with standard automated perimetry (SAP).
Fifteen patients with asymmetrical glaucoma, whose better eye was normal or near normal (mean deviations better than -3 dB) on SAP, were tested. SITA 24-2 standard and OCT RNFL thickness measures were made on three to five different occasions and the mean values were obtained. For each eye, the mean SAP loss was calculated for an upper and lower arcuate field region by averaging the loss in relative sensitivity on a linear scale. The average RNFL thickness for corresponding arcuate sectors of the lower and upper optic disc was obtained for each eye. A linear model was fitted to the plots of RNFL thickness versus SAP loss. According to the linear model, the RNFL thickness R = s(o)T + b, where T is the SAP sensitivity loss relative to age-matched normal eyes (linear scale), (s(o) + b) is the RNFL thickness in the healthy/normal state (T = 1), and b is the residual RNFL thickness measured when all sensitivity and all axons are lost.
The model provided a reasonable fit to the data with best fitting values of (s(o); b) of (upper field: 80.6 microm; 50.5 microm) and (lower field: 67.4 microm; 50.5 microm) and (upper field: 78.8 microm; 54.9 microm; r = 0.82) and (lower field: 59.2 microm; 61.5 microm; r = 0.70) for two different methods of best fit.
A linear model that relates RNFL thickness to losses in SAP sensitivity describes the results for arcuate regions of glaucomatous visual fields. The linear model provides a framework for assessing the relative efficacy of structural and functional tests throughout the course of the disease.
评估一种线性模型，该模型将通过光学相干断层扫描（OCT）测量的视网膜神经纤维层（RNFL）厚度的青光眼性损失与通过标准自动视野计（SAP）测量的敏感度损失相关联。
对15例不对称性青光眼患者进行测试，这些患者的较好眼在SAP检查中正常或接近正常（平均偏差优于-3 dB）。在三到五个不同时间进行SITA 24-2标准和OCT RNFL厚度测量，并获得平均值。对于每只眼睛，通过在线性尺度上平均相对敏感度损失，计算上、下弓形视野区域的平均SAP损失。为每只眼睛获取下部和上部视盘相应弓形扇区的平均RNFL厚度。将线性模型拟合到RNFL厚度与SAP损失的图上。根据线性模型，RNFL厚度R = s(o)T + b，其中T是相对于年龄匹配的正常眼睛的SAP敏感度损失（线性尺度），(s(o) + b)是健康/正常状态下的RNFL厚度（T = 1），b是当所有敏感度和所有轴突丧失时测量的残余RNFL厚度。
该模型对数据提供了合理的拟合，对于两种不同的最佳拟合方法，（s(o); b）的最佳拟合值为（上视野：80.6微米；50.5微米）和（下视野：67.4微米；50.5微米）以及（上视野：78.8微米；54.9微米；r = 0.82）和（下视野：59.2微米；61.5微米；r = 0.70）。
将RNFL厚度与SAP敏感度损失相关联的线性模型描述了青光眼视野弓形区域的结果。该线性模型为评估疾病全过程中结构和功能测试的相对疗效提供了一个框架。
