Kario K, Matsuo T, Nakao K
Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Japan.
Gerontology. 1991;37(6):345-8. doi: 10.1159/000213283.
We evaluated the relationship between erythropoietin (EPO) and hemoglobin (Hb) concentrations in 156 normal subjects ranging from 60 to 98 years old. EPO was determined by a radioimmunoassay. The serum EPO concentration in subjects with Hb concentrations greater than 12.0 g/dl (26.9 +/- 15.2 mU/ml), was significantly higher than that in younger controls (15.8 +/- 5.0 mU/ml, p less than 0.001). No sex difference in serum EPO level was detected. In addition, there was an inverse semilogarithmic relationship between EPO and Hb concentrations in subjects with Hb concentrations less than 12.0 g/dl (r = -0.559, p less than 0.001). EPO concentrations in the elderly were lower than those in young subjects with iron deficiency anemia with the same Hb level. Thus, in the elderly, a high EPO concentration may be preventing a decrease in the Hb concentration. However, a decreased EPO response to low Hb concentrations may be a contributing factor in anemia in the elderly.
我们评估了156名年龄在60至98岁之间的正常受试者中促红细胞生成素（EPO）与血红蛋白（Hb）浓度之间的关系。EPO通过放射免疫测定法测定。Hb浓度大于12.0 g/dl的受试者血清EPO浓度（26.9±15.2 mU/ml）显著高于年轻对照组（15.8±5.0 mU/ml，p<0.001）。未检测到血清EPO水平存在性别差异。此外，Hb浓度低于12.0 g/dl的受试者中，EPO与Hb浓度之间存在半对数反比关系（r = -0.559，p<0.001）。老年人的EPO浓度低于相同Hb水平的缺铁性贫血年轻受试者。因此，在老年人中，高EPO浓度可能在防止Hb浓度降低。然而，EPO对低Hb浓度的反应降低可能是老年人贫血的一个促成因素。
