Iribarren C
Division of Research, Northern California Kaiser Permanente, Oakland, CA 94612, USA.
Minerva Cardioangiol. 2007 Aug;55(4):487-9.
The usefulness of the metabolic syndrome is subject of debate. A central issue from the epidemiological perspective is whether the syndrome predicts cardiovascular disease above and beyond its individual components. In this paper, the current evidence regarding this matter is reviewed, and the conclusion of two recent studies is that there is no added predictive value of the syndrome when the individual components are in the model. Rather than perpetuate an arbitrary concept and create another disease entity, attention should be redirected to the individual components and, in particular, to the ''driving'' condition whose downstream consequences are serious in terms of morbidity and mortality: central or visceral obesity.
代谢综合征的实用性存在争议。从流行病学角度来看,一个核心问题是该综合征对心血管疾病的预测作用是否超出其各个组成部分单独的预测作用。本文回顾了关于这一问题的现有证据,两项近期研究的结论是,当各个组成部分纳入模型时,该综合征并无额外的预测价值。与其延续一个随意的概念并创造另一个疾病实体,不如将注意力重新转向各个组成部分,尤其是转向那种其下游后果在发病率和死亡率方面都很严重的“驱动性”病症:中心性肥胖或内脏性肥胖。