Agoşton-Coldea Lucica, Mocan Teodora, Rusu L D, Pais Raluca, Albu Adriana, Rusu M L, Perna S
Department of Medical Sciences, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Rom J Intern Med. 2008;46(1):55-62.
The subjects with metabolic syndrome are an increased risk for the development of diabetes mellitus and cardiovascular disease as well as an increased mortality for cardiovascular disease in all causes. The prevalence of the metabolic syndrome after acute coronary syndrome has not been studied yet. We aimed to evaluate the prevalence of the metabolic syndrome and to evaluate its cardiovascular risk potential using the National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III) criteria.
We performed a cross sectional study in 256 patients with acute coronary syndrome. The definition of the metabolic syndrome was based on NCEP-ATP III criteria. The cardiovascular risk factors that define the metabolic syndrome and their correlation with the cardiovascular risk were evaluated by descriptive and interferential statistical methods.
The prevalence of metabolic syndrome was 47.26%, as assessed by criteria of the NCEP-ATP III. The presence of the metabolic syndrome has been positively correlated with the cardiovascular risk (OR 1.29; 95% CI, 1.05-1.54, p=0.047). The cardiovascular risk has significantly correlated with the increasing of the components number that defines the metabolic syndrome. Among the components of the metabolic syndrome, HDL-Cholesterol was the most significantly correlated with the cardiovascular risk in the patients with acute coronary syndrome (OR 3.60; 95% CI 2.14-5.06; p=0.002).
The prevalence of the metabolic syndrome according to the NCEP-ATP III criteria was high, and positively correlated with the cardiovascular risk in the patients with acute coronary syndrome. The cardiovascular risk rises proportionally with the number of metabolic components.
患有代谢综合征的个体患糖尿病和心血管疾病的风险增加，且各种原因导致的心血管疾病死亡率也升高。急性冠状动脉综合征后代谢综合征的患病率尚未得到研究。我们旨在使用美国国家胆固醇教育计划成人治疗组第三次报告（NCEP-ATP III）标准评估代谢综合征的患病率，并评估其心血管疾病风险潜力。
我们对256例急性冠状动脉综合征患者进行了横断面研究。代谢综合征的定义基于NCEP-ATP III标准。通过描述性和推断性统计方法评估定义代谢综合征的心血管危险因素及其与心血管疾病风险的相关性。
根据NCEP-ATP III标准评估，代谢综合征的患病率为47.26%。代谢综合征的存在与心血管疾病风险呈正相关（比值比1.29；95%可信区间，1.05-1.54，p=0.047）。心血管疾病风险与定义代谢综合征的组分数量增加显著相关。在代谢综合征的组分中，高密度脂蛋白胆固醇与急性冠状动脉综合征患者的心血管疾病风险相关性最为显著（比值比3.60；95%可信区间2.14-5.06；p=0.002）。
根据NCEP-ATP III标准，代谢综合征的患病率较高，且与急性冠状动脉综合征患者的心血管疾病风险呈正相关。心血管疾病风险随代谢组分数量成比例增加。
