Stephane Massoud, Pellizzer Giuseppe, Fletcher Charles R, McClannahan Kate
Domenici Research Center for Mental Illness, VA Medical Center, Minneapolis, MN 55417, USA.
J Psychiatry Neurosci. 2007 Jul;32(4):250-8.
Studies of the content of speech and of verbal hallucinations in schizophrenia point to dysfunction at multiple levels of language. In this study, we empirically evaluated language processes.
We examined the performance of 22 schizophrenia patients and 11 healthy control subjects with procedures designed to explore the sublexical, lexical, semantic, syntactic and discourse levels of language processing.
Schizophrenia patients exhibit impairment in the recognition of incorrect, but not correct, linguistic stimuli at all but the sublexical level of language processing. The patients were not impaired in the recognition of nonlinguistic stimuli.
This language-specific differential impairment could explain speech abnormalities in schizophrenia. The nonrecognition of incorrect linguistic information would prevent patients from correcting the abnormal speech they may occasionally produce. A model of decreased power of linguistic computations (reduced number of operations) adequately accounts for this differential impairment.
对精神分裂症患者言语内容和言语幻觉的研究表明,语言的多个层面存在功能障碍。在本研究中,我们对语言加工过程进行了实证评估。
我们采用旨在探究语言加工的次词汇、词汇、语义、句法和语篇层面的程序,对22名精神分裂症患者和11名健康对照者的表现进行了检查。
除语言加工的次词汇层面外,精神分裂症患者在识别错误(而非正确)语言刺激方面均表现出损伤。患者在识别非语言刺激方面未受损。
这种特定于语言的差异损伤可以解释精神分裂症患者的言语异常。无法识别错误的语言信息会阻碍患者纠正他们偶尔可能产生的异常言语。语言计算能力下降(操作数量减少)的模型足以解释这种差异损伤。