Desarkar Pushpal, Sinha Vinod Kumar, Jagadheesan Karuppiah, Nizamie Shamshul Haque
Centre for Cognitive Neuroscience, Central Institute of Psychiatry, Ranchi, Jharkhand, India.
World J Biol Psychiatry. 2007;8(3):196-200. doi: 10.1080/15622970601148547.
Given the paucity of quantitative EEG studies using coherence measures to understand the electrophysiological functional integrity of sub-cortical structures in obsessive-compulsive disorder, the current study was carried out.
We obtained EEG coherence values for 20 adult OCD patients (10 males; 10 females) and 19 appropriately matched healthy controls across delta (0.5-3.5 Hz), theta (4-7.5 Hz), alpha (8-12 Hz), beta1 (12.5-20 Hz) and beta2 (20.5-30 Hz) bands. As coherence between distant brain regions reflects physiological activities at sub-cortical neural networks, we chose EEG channels at four distant brain regions - anterior interhemispheric, posterior interhemispheric, fronto-temporal and fronto-occipital.
In comparison to controls we found significant increase of theta band EEG coherence in the fronto-occipital region in OCD patients (P = 0.045) which did not correlate significantly with either medication status or disease severity.
This EEG coherence study that suggests hyperactivity at subcortical circuitry in OCD patients is in agreement with existing neuro-imaging findings. Furthermore, this finding provides external validity for sub-cortical dysfunction hypothesis of OCD.
鉴于利用相干性测量进行定量脑电图研究以了解强迫症患者皮质下结构的电生理功能完整性的研究较少，故开展了本研究。
我们获取了20名成年强迫症患者（10名男性；10名女性）和19名匹配良好的健康对照者在δ波（0.5 - 3.5赫兹）、θ波（4 - 7.5赫兹）、α波（8 - 12赫兹）、β1波（12.5 - 20赫兹）和β2波（20.5 - 30赫兹）频段的脑电图相干值。由于远距离脑区之间的相干性反映了皮质下神经网络的生理活动，我们选择了四个远距离脑区的脑电图通道——前半球间、后半球间、额颞和额枕。
与对照组相比，我们发现强迫症患者额枕区的θ波频段脑电图相干性显著增加（P = 0.045），且与用药状态或疾病严重程度均无显著相关性。
这项脑电图相干性研究表明强迫症患者皮质下回路活动亢进，这与现有的神经影像学研究结果一致。此外，这一发现为强迫症的皮质下功能障碍假说提供了外部效度。
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