Department of Neurology, Clinical Neurophysiology, Neurorehabilitation, Institute of Experimental Neurology, IRCCS University Hospital San Raffaele, Via Olgettina 60, Milan, Italy.
Neuroimage. 2010 Jan 1;49(1):977-83. doi: 10.1016/j.neuroimage.2009.08.015. Epub 2009 Aug 13.
Morphological and functional studies suggested involvement of several cortical and subcortical circuitries in patients with obsessive-compulsive disorder (OCD). The aim of the present study was to investigate networks involved in OCD pathophysiology, using power (coupling of EEG bands, low-resolution electromagnetic tomography-LORETA) and coherence analysis in drug-naïve patients.
EEG was obtained from 37 drug-naïve patients with OCD and 37 age- and sex-matched controls. Resting EEG was recorded from 29 scalp channels. Coupling (ratio and correlation) between low and high frequencies was analyzed on Fz. For each frequency band, LORETA current density distribution, intra-hemispheric and inter-hemispheric coherence analysis were computed.
OCD had increased current density for delta in the insula and for beta in frontal, parietal and limbic lobes. OCD also had decreased inter-hemispheric coherence and reduced coupling between delta and beta frequencies.
In OCD, increased frontal beta is consistent with previous evidence of frontal dysfunction. Hyperactivity of insular delta sources, together with rhythms decoupling and reduced interhemispheric alpha coherence are consistent with additional involvement of cortico-subcortical functional connections. Combined use of power and coherence analysis may provide functional measures on different levels of involvement of cortico-subcortical circuits in neuropsychiatric disorders.
形态学和功能研究表明，强迫症（OCD）患者涉及多个皮质和皮质下回路。本研究的目的是使用药物初治患者的功率（脑电波段耦合、低分辨率电磁断层成像-LORETA）和相干分析来研究 OCD 病理生理学相关的网络。
对 37 名药物初治 OCD 患者和 37 名年龄和性别匹配的对照者进行 EEG 检查。EEG 记录来自 29 个头皮通道。在 Fz 上分析低频和高频之间的耦合（比值和相关性）。对于每个频带，计算 LORETA 电流密度分布、半球内和半球间相干性分析。
OCD 患者岛叶的 delta 波和额叶、顶叶和边缘叶的 beta 波电流密度增加。OCD 患者还存在半球间相干性降低和 delta 和 beta 频率之间耦合减少的现象。
在 OCD 中，额叶的 beta 增加与先前额叶功能障碍的证据一致。岛叶 delta 源的过度活跃，以及节律解耦和 alpha 相干性降低，与皮质下功能连接的额外参与一致。功率和相干性分析的联合使用可能会为神经精神障碍皮质下回路不同程度的参与提供功能指标。
