Pogarell Oliver, Juckel Georg, Mavrogiorgou Paraskevi, Mulert Christoph, Folkerts Malte, Hauke Walter, Zaudig Michael, Möller Hans-Jürgen, Hegerl Ulrich
Department of Psychiatry, Division of Clinical Neurophysiology, Ludwig-Maximilians-University of Munich, Germany.
Int J Psychophysiol. 2006 Oct;62(1):87-92. doi: 10.1016/j.ijpsycho.2006.02.002. Epub 2006 Mar 22.
Neurophysiological studies in patients with obsessive-compulsive disorder (OCD) consistently revealed frontal alterations of cortical activity but otherwise showed inhomogeneous results, conceivably due to variable subgroups with diverse pathomechanisms involved. The aim of this study was to investigate quantitative electroencephalography (EEG) in patients with OCD as compared to healthy controls and to correlate neurophysiological data with clinical variables. EEGs were digitally recorded from 18 unmedicated patients (8 male, mean age 32.4+/-11.8 years, Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) 15.3+/-7.9) and 18 matched healthy controls, and analysed quantitatively. The mean frequency of EEG background activity and absolute power in delta, theta, alpha and beta frequency bands were calculated. Mean frequency of background activity was significantly lower in patients as compared to controls (-1.44/s, p<0.01), predominantly for the frontal electrode positions. Power spectra revealed increased delta- and decreased alpha-/beta-power in the group of patients (p<0.05, patients vs. controls). Correlation analyses showed significant positive correlations of EEG-power with the Y-BOCS sub-scores "obsessions", and negative correlations with the sub-scores "compulsions" (Spearman's correlations, r(s)=+0.48 to +0.70, and -0.47 to -0.6, respectively, p<0.05). The data provide evidence of a dysfunction of frontal cortical activity in patients with OCD. The opposite correlations of neurophysiological data and clinical features, i.e. obsessions and compulsions, are suggestive of pathophysiological differences based on the presence of the respective cardinal symptoms of OCD.
对强迫症（OCD）患者的神经生理学研究一直显示出额叶皮质活动的改变，但其他方面的结果却不一致，这可能是由于涉及不同病理机制的可变亚组所致。本研究的目的是调查强迫症患者与健康对照者的定量脑电图（EEG），并将神经生理学数据与临床变量相关联。对18名未接受药物治疗的患者（8名男性，平均年龄32.4±11.8岁，耶鲁-布朗强迫症量表（Y-BOCS）评分为15.3±7.9）和18名匹配的健康对照者进行了EEG数字记录，并进行了定量分析。计算了EEG背景活动的平均频率以及δ、θ、α和β频段的绝对功率。与对照组相比，患者的背景活动平均频率显著降低（-1.44/s，p<0.01），主要是额叶电极位置。功率谱显示患者组的δ功率增加，α/β功率降低（p<0.05，患者与对照组相比）。相关性分析显示EEG功率与Y-BOCS子评分“强迫观念”呈显著正相关，与子评分“强迫行为”呈负相关（斯皮尔曼相关性，r(s)分别为+0.48至+0.70和-0.47至-（此处原文似乎有误，推测应为-0.6），p<0.05）。这些数据为强迫症患者额叶皮质活动功能障碍提供了证据。神经生理学数据与临床特征（即强迫观念和强迫行为）的相反相关性表明，基于强迫症各自主要症状的存在存在病理生理学差异。
