牛黄上清丸对脑缺血保护作用的研究
[Studies on protective effects of Niuhuang Shangqing pills on cerebral ischemia].
作者信息
Zhang Lei, Zhao Yong, Zhang Lei, Liu Ting, Li Chun-Ying, Jin Ran, Zhou Lei, Li Jian-Rong
机构信息
Institute of Chinese Materia Medica, China Academy of Chinese Medicial Sciences, Beijing 100700, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2007 May;32(10):943-8.
OBJECTIVE
To discuss the protective effect of Niuhuang Shangqing pills (NSP) on the experimental cerebral ischemia and the influence of blood rheology in animals.
METHOD
Using the middle cerebral artery occlusion (MCAO), bilateral common carotid artery ligation and lipopolysaccharide (LPS) in combination with carrogeenin (Ca)-induced stagnation of blood model rats, we investigated the influence of NSP on the physical sign indexes, brain infarct size and the water content, the content of lactate(LD), glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA) and the blood rheology.
RESULT
The 3.00, 1.50 g x kg(-1) dosage groups of NSP decreased the neurosigns indexes, significantly reduced the brain infarct areas in MCAO rats, decreased the brain water content, increased the activities of GPx and CAT, decreased the content of LD and MDA in bilateral common carotid artery ligation rats. They improved the blood rheology in lipopolysaccharide (LPS) in combination with carrogeenin (Ca)-induced stagnation of blood model rats.
CONCLUSION
NSP has the function of protective effect on experimental experimental cerebral ischemia.
目的
探讨牛黄上清丸对实验性脑缺血的保护作用及对动物血液流变学的影响。
方法
采用大脑中动脉闭塞（MCAO）、双侧颈总动脉结扎以及脂多糖（LPS）联合角叉菜胶（Ca）诱导的血瘀模型大鼠，研究牛黄上清丸对体征指标、脑梗死体积和含水量、乳酸（LD）含量、谷胱甘肽过氧化物酶（GPx）、过氧化氢酶（CAT）、丙二醛（MDA）含量以及血液流变学的影响。
结果
牛黄上清丸3.00、1.50 g·kg⁻¹剂量组可降低体征指标，显著缩小MCAO大鼠的脑梗死面积，降低脑含水量，提高双侧颈总动脉结扎大鼠的GPx和CAT活性，降低LD和MDA含量。改善脂多糖（LPS）联合角叉菜胶（Ca）诱导的血瘀模型大鼠的血液流变学。
结论
牛黄上清丸对实验性脑缺血具有保护作用。
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