Yoo S Y, Jang J H, Shin Y-W, Kim D J, Park H-J, Moon W-J, Chung E C, Lee J-M, Kim I Y, Kim S I, Kwon J S
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
Acta Psychiatr Scand. 2007 Sep;116(3):211-9. doi: 10.1111/j.1600-0447.2007.01046.x.
The aim was to investigate the white matter abnormalities of drug-naïve patients with obsessive-compulsive disorder (OCD) using diffusion tensor-imaging and the white matter changes in the patients after pharmacotherapy.
Thirteen drug-naïve OCD patients and 13 age- and sex-matched healthy comparison subjects were examined using diffusion tensor-imaging and structural magnetic resonance imaging. Measurements were made in OCD patients before and after 12 weeks of citalopram treatment.
Compared with controls, the drug-naïve OCD patients showed significant increases in fractional anisotropy (FA) in the corpus callosum, the internal capsule and white matter in the area superolateral to the right caudate. The increases in FA were mostly no longer observed in patients after 12 weeks of treatment compared with controls.
Our findings suggest that white matter alterations are associated with the pathophysiology of OCD, and the abnormalities may be partly reversible with pharmacotherapy.
旨在利用扩散张量成像研究未接受过药物治疗的强迫症（OCD）患者的白质异常情况以及药物治疗后患者的白质变化。
对13名未接受过药物治疗的强迫症患者和13名年龄及性别匹配的健康对照者进行扩散张量成像和结构磁共振成像检查。对强迫症患者在接受西酞普兰治疗12周前后进行测量。
与对照组相比，未接受过药物治疗的强迫症患者在胼胝体、内囊以及右侧尾状核上外侧区域的白质中，分数各向异性（FA）显著增加。与对照组相比，治疗12周后的患者中，FA的增加大多不再明显。
我们的研究结果表明，白质改变与强迫症的病理生理学相关，且这些异常情况可能通过药物治疗部分逆转。
