Prosseda Gianni, Carmela Latella Maria, Barbagallo Marialuisa, Nicoletti Mauro, Al Kassas Rasha, Casalino Mariassunta, Colonna Bianca
Istituto Pasteur-Fondazione Cenci Bolognetti, Dip. Biologia Cellulare e dello Sviluppo, Sapienza-Università di Roma, Via dei Sardi 70, 00185 Rome, Italy.
Res Microbiol. 2007 Jul-Aug;158(6):487-93. doi: 10.1016/j.resmic.2007.05.001. Epub 2007 May 21.
In enterobacteria, acid stress induces expression of the cad system which is involved in maintaining intracellular pH at levels compatible with cell survival. Despite its crucial role, the cad operon is silenced in Shigella and in other pathogenic Escherichia coli. In the present review, we will address the question of why and how the cad locus has been sacrificed for the sake of optimal expression of virulence traits.
在肠杆菌中，酸应激会诱导cad系统的表达，该系统参与将细胞内pH维持在与细胞存活相容的水平。尽管其具有关键作用，但cad操纵子在志贺氏菌和其他致病性大肠杆菌中是沉默的。在本综述中，我们将探讨为了毒力特征的最佳表达而牺牲cad基因座的原因及方式。
