Chattopadhyay Sankha, Pal Sujit, Vimalnath K V, Das M K
Radiopharmaceuticals Laboratory, Board of Radiation and Isotope Technology (BRIT), Variable Energy Cyclotron Centre (VECC), 1/AF, Bidhan Nagar, Kolkata 700 064, India.
Appl Radiat Isot. 2007 Nov;65(11):1202-7. doi: 10.1016/j.apradiso.2007.05.010. Epub 2007 Jun 26.
A method for the separation of no-carrier-added (nca) arsenic radionuclides from bulk amounts of irradiated germanium oxide (GeO2) target was developed in view of their potentialities in different biological and nuclear medicine applications. The beta- emitting 77As radionuclide, produced by the decay of 77Ge through the natGe(n,gamma)77Ge nuclear reaction, was used for standardization of the radiochemical separation procedure. The radiochemical separation was performed by precipitation followed by solvent extraction. About 99% post-irradiation recovery of the GeO2 target material, in a form suitable for reuse in future irradiation, was achieved. The developed method was suitable for the production of nca arsenic radionuclides either as trivalent or pentavalent arsenic in various vehicles which provided flexibility of formulations of different kinds of compound. The overall radiochemical yield for the complete separation of 77As was 90%. The separated nca 77As was of high radionuclidic purity and did not contain detectable amounts of the target material. This method can be adopted for the radiochemical separation of other different arsenic radionuclides produced from GeO2 through cyclotron as well as reactor irradiation.
鉴于无载体添加（nca）砷放射性核素在不同生物和核医学应用中的潜力，开发了一种从大量辐照氧化锗（GeO₂）靶材中分离它们的方法。通过天然锗（Ge）的（n，γ）反应，由⁷⁷Ge衰变产生的发射β射线的⁷⁷As放射性核素用于放射化学分离程序的标准化。放射化学分离通过沉淀随后进行溶剂萃取来进行。实现了约99%的辐照后GeO₂靶材回收，回收形式适合未来辐照再利用。所开发的方法适用于在各种载体中生产三价或五价砷形式的nca砷放射性核素，这为不同种类化合物的配方提供了灵活性。完全分离⁷⁷As的总放射化学产率为90%。分离出的nca⁷⁷As具有高放射性核纯度，且不含可检测量的靶材。该方法可用于通过回旋加速器以及反应堆辐照从GeO₂产生的其他不同砷放射性核素的放射化学分离。
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