一种从辐照氧化锗中放射化学分离砷的新方法。
A new method for radiochemical separation of arsenic from irradiated germanium oxide.
作者信息
Jennewein M, Qaim S M, Hermanne A, Jahn M, Tsyganov E, Slavine N, Seliounine S, Antich P A, Kulkarni P V, Thorpe P E, Mason R P, Rösch F
机构信息
Institute of Nuclear Chemistry, Johannes Gutenberg University of Mainz, Fritz-Strassmann-Weg 2, 55128 Mainz, Germany.
出版信息
Appl Radiat Isot. 2005 Sep;63(3):343-51. doi: 10.1016/j.apradiso.2005.04.005.
Radioarsenic labelled radiopharmaceuticals could be a valuable asset to Positron Emission Tomography (PET). In particular, the long half-lives of (72)As (T(1/2)=26 h) and (74)As (T(1/2)=17.8 d) allow to investigate slow physiological or metabolical processes, like the enrichment and distribution of antibodies in tumor tissue. This work describes the direct production of no-carrier-added (nca) arsenic isotopes *As, with *=71, 72, 73, 74 or 77, the reaction to [*As]AsI(3) and its radiochemical separation from the irradiated solid germanium oxide via polystyrene-based solid-phase extraction. The germanium oxide target, irradiated at a cyclotron or a nuclear reactor, is dissolved in concentrated HF and Ge is separated almost quantitatively (99.97%) as GeF(6). [*As]AsI(3) is formed by addition of potassium iodide. The radiochemical separation yield for arsenic is >90%. [*As]AsI(3) is a versatile radioarsenic labelling synthon.
放射性砷标记的放射性药物可能是正电子发射断层扫描（PET）的一项宝贵资产。特别是，（72）As（T（1/2）=26小时）和（74）As（T（1/2）=17.8天）的长半衰期使得能够研究缓慢的生理或代谢过程，如抗体在肿瘤组织中的富集和分布。这项工作描述了无载体添加（nca）砷同位素As（ = 71、72、73、74或77）的直接生产、与[*As]AsI（3）的反应以及通过基于聚苯乙烯的固相萃取从辐照的固体氧化锗中进行放射化学分离。在回旋加速器或核反应堆中辐照的氧化锗靶溶解在浓HF中，Ge几乎定量地（99.97%）以[GeF（6）]（2-）形式分离出来。通过加入碘化钾形成[*As]AsI（3）。砷的放射化学分离产率>90%。[*As]AsI（3）是一种通用的放射性砷标记合成子。
Zotero 插件