Veraldi Stefano, Bottini Silvia, Persico Maria Chiara, Lunardon Luisa
Institute of Dermatological Sciences, University of Milan, Milan, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Nov;104(5):659-61. doi: 10.1016/j.tripleo.2007.02.014. Epub 2007 Jul 25.
We report a case of leishmaniasis localized to the upper lip in a 77-year-old Italian man. The disease was characterized by a severe swelling which involved the right side of the upper lip. The swelling was slightly erythematous with crusts and scaling. Consistency was parenchymatous-hard. The lesion was asymptomatic. Histopathologic examination showed an inflammatory infiltrate consisting of lymphocytes, histiocytes, and plasma cells. Several Leishmania spp. amastigotes were observed in the cytoplasm of macrophages. Cultural examination on Novy-MacNeal-Nicolle medium was positive for Leishmania spp. Polymerase chain reaction was positive for Leishmania infantum. The patient was treated with i.m. N-methylglucamine antimonate, with complete remission in approximately 6 weeks. During follow-up of 9 months, no relapses were observed.
我们报告了一例77岁意大利男性上唇局限性利什曼病的病例。该病的特征为严重肿胀，累及上唇右侧。肿胀处轻度红斑，伴有结痂和脱屑。质地为实质硬。病变无明显症状。组织病理学检查显示炎症浸润由淋巴细胞、组织细胞和浆细胞组成。在巨噬细胞的细胞质中观察到数个利什曼原虫属无鞭毛体。在诺维-麦克尼尔-尼科尔培养基上的培养检查显示利什曼原虫属阳性。聚合酶链反应显示婴儿利什曼原虫阳性。患者接受肌肉注射甲基葡胺锑酸盐治疗，约6周后完全缓解。在9个月的随访期间，未观察到复发情况。
