Jongejan Frans, Nene Vishvanath, de la Fuente Jose, Pain Arnab, Willadsen Peter
Trends Parasitol. 2007 Sep;23(9):391-6. doi: 10.1016/j.pt.2007.07.004. Epub 2007 Jul 26.
Ticks and the diseases for which they are vectors engage in complex interactions with their mammalian hosts. These interactions involve the developmental processes of tick and pathogen, and interplay between the defensive responses and counter responses of host, tick and pathogen. Understanding these interactions has long been an intractable problem, but progress is now being made thanks to the flood of genomic information on host, tick and pathogen, and the attendant, novel experimental tools that have been generated. Each advance reveals new levels of complexity, but there are encouraging signs that genomics is leading to novel means of parasite control.
蜱虫及其作为传播媒介的疾病与它们的哺乳动物宿主之间存在着复杂的相互作用。这些相互作用涉及蜱虫和病原体的发育过程，以及宿主、蜱虫和病原体的防御反应与反击反应之间的相互作用。长期以来，理解这些相互作用一直是个棘手的问题，但由于宿主、蜱虫和病原体的基因组信息大量涌现，以及随之产生的新型实验工具，目前正在取得进展。每一项进展都揭示了新的复杂层面，但有令人鼓舞的迹象表明，基因组学正在带来寄生虫控制的新方法。
