Ortega-Martínez Olga, Pernas Monica, Carol Rachel J, Dolan Liam
Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK.
Science. 2007 Jul 27;317(5837):507-10. doi: 10.1126/science.1143409.
The construction of multicellular organisms depends on stem cells-cells that can both regenerate and produce daughter cells that undergo differentiation. Here, we show that the gaseous messenger ethylene modulates cell division in the cells of the quiescent center, which act as a source of stem cells in the seedling root. The cells formed through these ethylene-induced divisions express quiescent center-specific genes and can repress differentiation of surrounding initial cells, showing that quiescence is not required for these cells to signal to adjacent stem cells. We propose that ethylene is part of a signaling pathway that modulates cell division in the quiescent center in the stem cell niche during the postembryonic development of the root system.
多细胞生物的构建依赖于干细胞，即既能再生又能产生经历分化的子细胞的细胞。在此，我们表明气态信使乙烯可调节静止中心细胞的细胞分裂，静止中心细胞是幼苗根中干细胞的来源。通过这些乙烯诱导的分裂形成的细胞表达静止中心特异性基因，并能抑制周围起始细胞的分化，这表明这些细胞向相邻干细胞发出信号并不需要静止状态。我们提出，乙烯是根系胚胎后发育过程中调节干细胞微环境中静止中心细胞分裂的信号通路的一部分。
