Berrevoet Frederik, de Hemptinne Bernard
Department of General Surgery, Division of Hepatobiliary Surgery and Liver Transplantation Service, Ghent University Hospital Medical School, Ghent, Belgium.
Dig Surg. 2007;24(4):288-93. doi: 10.1159/000103660. Epub 2007 Jul 27.
Despite all recent developments in surgical techniques during liver surgery, blood loss is still one of the main causes for postoperative morbidity and mortality. Other complications include bile leakage and fluid accumulation intraperitoneally. Fibrin sealants are able not only to enhance clot formation and wound healing but possibly work as a sealing device for postoperative leakage and fistula formation. In this overview the underlying mechanisms for these agents are discussed and several clinical data concerning liver surgery will be reported.
尽管肝脏手术的外科技术最近有了所有进展，但失血仍然是术后发病和死亡的主要原因之一。其他并发症包括胆漏和腹腔内积液。纤维蛋白密封剂不仅能够增强凝血形成和伤口愈合，而且可能作为术后渗漏和瘘管形成的密封装置。在本综述中，将讨论这些药物的潜在机制，并报告一些关于肝脏手术的临床数据。
