Rossi L, Squitti R, Calabrese L, Rotilio G, Rossini P M
Department of Biology Tor Vergata University of Rome, Via della Ricerca Scientifica, 00133 Rome, Italy.
J Nutr Health Aging. 2007 Sep-Oct;11(5):408-17.
Alzheimer's disease represents a growing health problem because of the ongoing increase in life expectancy. Therefore understanding the molecular alterations responsible for neurodegeneration has become imperative in order to develop efficient strategies for the therapy. Mounting evidence suggests that the essential metal ion copper is intriguingly connected with the established molecular markers of Alzheimer's disease and that copper homeostasis is disturbed in affected individuals, leading to oxidative stress and neurodegeneration. This review summarizes the mechanisms of copper trafficking in cells and describes the relationship between copper, the amyloid precursor protein and beta-amyloid. Since one of the main goals of the research on Alzheimer's disease is the identification of blood markers to aid diagnosis and monitor the effects of therapeutic approaches, the results obtained in a series of studies on copper in the blood of Alzheimer's disease patients recently carried out in our laboratories are described.
由于预期寿命不断增加，阿尔茨海默病已成为一个日益严重的健康问题。因此，为了开发有效的治疗策略，了解导致神经退行性变的分子改变已变得势在必行。越来越多的证据表明，必需金属离子铜与阿尔茨海默病已确立的分子标志物有着有趣的联系，并且在受影响个体中铜稳态受到干扰，导致氧化应激和神经退行性变。本综述总结了细胞中铜转运的机制，并描述了铜、淀粉样前体蛋白和β-淀粉样蛋白之间的关系。由于阿尔茨海默病研究的主要目标之一是识别血液标志物以辅助诊断并监测治疗方法的效果，因此本文描述了我们实验室最近对阿尔茨海默病患者血液中的铜进行的一系列研究所得出的结果。
