Hoda Q, Sinha S P
Department of Zoology, Bhagalpur University, India.
J Nutr Sci Vitaminol (Tokyo). 1991 Aug;37(4):329-39. doi: 10.3177/jnsv.37.329.
Genotoxic effect of agriculture-used concentration of organophosphorous pesticide, Malathion, is decreased by the dietary concentration of sodium salt of L-ascorbic acid for parameters like mitotic-index and clastogeny in onion root-tip cells, clastogeny and meiotic-index in mice, and lethal mutation rate in Drosophila melanogaster. The vitamin itself is not genotoxic, and its concurrent administration is more effective than pretreatment with it. Possible mechanism of such vitamin C-mediated minimization of pesticide-genotoxicity is discussed.
农业使用浓度的有机磷农药马拉硫磷的遗传毒性，在洋葱根尖细胞的有丝分裂指数和染色体畸变、小鼠的染色体畸变和减数分裂指数以及黑腹果蝇的致死突变率等参数方面，会因膳食中L-抗坏血酸钠的浓度而降低。该维生素本身无遗传毒性，同时给药比预处理更有效。本文讨论了这种维生素C介导的农药遗传毒性最小化的可能机制。
