Hoda Q, Sinha S P
Department of Zoology, Bhagalpur University, India.
Mutat Res. 1993 Mar;299(1):29-36. doi: 10.1016/0165-1218(93)90116-u.
The genotoxic effect of Rogor (an organophosphorous pesticide) at concentrations used in agriculture was studied in terms of mitotic index in onion root-tip cells, chromosome abnormalities and meiotic index in mice and lastly, lethal mutation rate in Drosophila. It was observed that the pesticide could (i) cause mitotic as well as meiotic inhibition, (ii) increase the clastogenicity rate and (iii) induce lethal mutations. The modificatory role, if any, of L-ascorbic acid (vitamin C) was studied after administering the vitamin concurrently with the pesticide. It was observed that the cytogenetic toxicity of Rogor can be appreciably minimised by vitamin C. The possible mode of antigenotoxic action of vitamin C was discussed.
研究了乐果（一种有机磷农药）在农业使用浓度下对洋葱根尖细胞有丝分裂指数、小鼠染色体异常和减数分裂指数以及果蝇致死突变率的遗传毒性作用。观察到该农药能够：（i）引起有丝分裂和减数分裂抑制；（ii）提高断裂形成率；（iii）诱导致死突变。在与农药同时给予维生素L-抗坏血酸（维生素C）后，研究了其可能存在的修饰作用。观察到维生素C可显著降低乐果的细胞遗传毒性。并讨论了维生素C抗遗传毒性作用的可能机制。
