Hoda Q, Azfer M A, Sinha S P
Department of Zoology, Aligarh Muslim University, India.
Int J Vitam Nutr Res. 1993;63(1):48-51.
Administration of organophosphorous pesticide Malathion and Rogor (both @ 0.2 micrograms/kg body wt/day) upto ten days was found to decrease the division rate in the primary spermatocytes of mice. The concurrent administration of vitamin B-complex (0.3 ml of 1% polybion) or ascorbic acid (0.25 ml of 1% Redoxon) with the pesticide could nullify the meiotic inhibition caused by the pesticides. The vitamins were not found to produce any significant effect on the division rate. Possible mechanism(s) behind this vitamin mediated nullification of meiotic inhibition are discussed.
研究发现，连续十天给予小鼠有机磷农药马拉硫磷和乐果（均为0.2微克/千克体重/天）会降低小鼠初级精母细胞的分裂率。同时给予复合维生素B（1%多种维生素0.3毫升）或抗坏血酸（1%力度伸0.25毫升）与农药，可以消除农药引起的减数分裂抑制。未发现这些维生素对分裂率有任何显著影响。文中讨论了这种维生素介导的减数分裂抑制消除背后可能的机制。
