Conti Cristiane Fiquene, de Oliveira Márcio Moysés, Andriolo Regis Bruni, Saconato Humberto, Atallah Alvaro Nagib, Valbuza Juliana Spelta, Coin de Carvalho Luciane Bizari, do Prado Gilmar Fernandes
Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
Mov Disord. 2007 Oct 15;22(13):1943-51. doi: 10.1002/mds.21662.
Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. The prevalence of RLS is estimated at 2.7 to 5% of adults and it is more common in women. The treatment of RLS with levodopa has been reported thus a systematic synthesis of evidence is necessary to evaluate the effectiveness and safety of levodopa for RLS. Systematic review of randomized or quasi-randomized, double blind trials on levodopa. Relief of restless legs symptoms marked on a validated scale, subjective sleep quality, sleep quality measured by night polysomnography and actigraphy, quality of life measured by subjective measures, adverse events associated with the treatments. Nine eligible clinical trials were included. The subjective analyses of these studies showed contradictory results, although the objective analyses showed that treatment group had a statistically significant improvement of periodic leg movement (PLM) index, favoring the treatment group. The most commonly adverse event seen was gastrointestinal symptoms. The short-term treatment with levodopa was demonstrated effective and safety for PLM, but there was only few trials assessing long-term treatment and the augmentation phenomenon in RLS. Further long-term randomized controlled trials using standard follow-up measurements as the International RLS Study Group Rating Scale are necessary.
不宁腿综合征（RLS）是一种感觉运动障碍，其特征是腿部以及有时身体其他部位有一种令人痛苦的想要活动的冲动，通常伴有腿部或其他受影响身体部位明显的不适感或疼痛。据估计，RLS在成年人中的患病率为2.7%至5%，且在女性中更为常见。已有关于用左旋多巴治疗RLS的报道，因此有必要对证据进行系统综合，以评估左旋多巴治疗RLS的有效性和安全性。对左旋多巴的随机或半随机、双盲试验进行系统评价。通过经过验证的量表评估不宁腿症状的缓解情况、主观睡眠质量、通过夜间多导睡眠图和活动记录仪测量的睡眠质量、通过主观测量方法测量的生活质量、与治疗相关的不良事件。纳入了9项符合条件的临床试验。这些研究的主观分析显示结果相互矛盾，尽管客观分析表明治疗组的周期性腿部运动（PLM）指数有统计学意义的改善，治疗组更具优势。最常见的不良事件是胃肠道症状。左旋多巴的短期治疗对PLM显示出有效性和安全性，但评估RLS长期治疗和增敏现象的试验很少。有必要开展进一步的长期随机对照试验，采用国际RLS研究组评分量表等标准随访测量方法。
