Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sleep. 2010 Jan;33(1):75-9. doi: 10.1093/sleep/33.1.75.
Dopaminergic hypofunction in the central nervous system may contribute to restless legs syndrome (RLS) and erectile dysfunction (ED). We therefore examined whether men with RLS have higher prevalences of ED.
RLS was assessed using a set of standardized questions. Men were considered to have RLS if they met 4 RLS diagnostic criteria recommended by the International RLS Study Group, and had restless legs > or = 5 times/month. Erectile function was assessed by a questionnaire.
Community-based.
23,119 men who participated in the Health Professional Follow-up Study free of diabetes and arthritis.
Multivariate-adjusted odds ratios for ED were 1.16 and 1.78 (95% confidence interval: 1.4, 2.3; P trend < 0.0001) for men with RLS symptoms 5-14 times/mo, and 15+ times/mo, respectively, relative to those without RLS, after adjusting for age, smoking, BMI, antidepressant use, and other covariates. The associations between RLS and ED persisted in subgroup analysis according to age, obesity, and smoking status.
Men with RLS had a higher likelihood of concurrent ED, and the magnitude of the observed association was increased with a higher frequency of RLS symptoms. These results suggest that ED and RLS share common determinants.
中枢神经系统多巴胺功能低下可能导致不宁腿综合征（RLS）和勃起功能障碍（ED）。因此，我们研究了 RLS 患者 ED 的发病率是否更高。
使用一组标准化问题评估 RLS。如果男性符合国际 RLS 研究组推荐的 4 项 RLS 诊断标准，且腿部不安>或=每月 5 次，则被认为患有 RLS。通过问卷评估勃起功能。
社区为基础。
23119 名参加健康专业人员随访研究且无糖尿病和关节炎的男性。
多变量调整后的 ED 比值比（OR）分别为 1.16 和 1.78（95%置信区间：1.4，2.3；P 趋势<0.0001），与无 RLS 症状的男性相比，RLS 症状每月 5-14 次和 15 次以上的男性分别为 1.16 和 1.78（95%置信区间：1.4，2.3；P 趋势<0.0001），调整年龄、吸烟、BMI、抗抑郁药使用和其他混杂因素后。根据年龄、肥胖和吸烟状况进行亚组分析，RLS 与 ED 之间的关联仍然存在。
患有 RLS 的男性发生 ED 的可能性更高，并且观察到的关联强度随着 RLS 症状频率的增加而增加。这些结果表明 ED 和 RLS 具有共同的决定因素。
