Freidlin Julie, Acharya Nisha, Lietman Thomas M, Cevallos Vicky, Whitcher John P, Margolis Todd P
F I Proctor Foundation, University of California, San Francisco, CA 94143, USA.
Am J Ophthalmol. 2007 Aug;144(2):313-5. doi: 10.1016/j.ajo.2007.03.032.
To compare the clinical features and antibiotic susceptibility of ocular methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).
Cross-sectional study.
The Proctor clinical laboratory database was reviewed to identify all ocular isolates of S. aureus collected between July 1, 1998 and July 31, 2006.
Of 915 S. aureus isolates, there were 88 MRSA isolates in 41 different patients. The proportion MRSA increased from 4.1% in 1998 to 1999 to 16.7% in 2005 to 2006. A total of 78.0% of patients with MRSA had blepharoconjunctivitis, 2.4% had cellulitis, 2.4% had dacryocystitis, 14.6% had keratitis, and 2.4% had endophthalmitis. The diagnoses associated with MSSA were not statistically different. A total of 63.6% of MRSA isolates were sensitive to bacitracin, 100% to vancomycin, 14.8% to ciprofloxacin, 14.8% to erythromycin, 97.7% to sulfisoxazole, and 93.2% to tetracycline.
MRSA has become a more common ocular pathogen but, as with MSSA, causes mild disease. MRSA should be treated with vancomycin.
比较眼部耐甲氧西林金黄色葡萄球菌（MRSA）和甲氧西林敏感金黄色葡萄球菌（MSSA）的临床特征及抗生素敏感性。
横断面研究。
回顾普罗克特临床实验室数据库，以识别1998年7月1日至2006年7月31日期间收集的所有眼部金黄色葡萄球菌分离株。
在915株金黄色葡萄球菌分离株中，41例不同患者中有88株MRSA分离株。MRSA的比例从1998年至1999年的4.1%增加到2005年至2006年的16.7%。共有78.0%的MRSA患者患有睑结膜炎，2.4%患有蜂窝织炎，2.4%患有泪囊炎，14.6%患有角膜炎，2.4%患有眼内炎。与MSSA相关的诊断无统计学差异。共有63.6%的MRSA分离株对杆菌肽敏感，100%对万古霉素敏感，14.8%对环丙沙星敏感，14.8%对红霉素敏感，97.7%对磺胺异恶唑敏感，93.2%对四环素敏感。
MRSA已成为一种更常见的眼部病原体，但与MSSA一样，引起的疾病较轻。MRSA应使用万古霉素治疗。
