Shanmuganathan V A, Armstrong M, Buller A, Tullo A B
Manchester Royal Eye Hospital, Manchester, UK.
Eye (Lond). 2005 Mar;19(3):284-91. doi: 10.1038/sj.eye.6701465.
To determine the prevalence and clinical characteristics of external ocular infections caused by methicillin-resistant Staphylococcus aureus (MRSA) in an ophthalmic hospital in the UK.
A retrospective analysis of the case notes of patients who had culture proven external ocular Staphylococcal infections during a 44-month period was undertaken.
There were a total of 548 external eye infections caused by Staphylococcus aureus. Of these, 17 (3%) were MRSA positive. The most common presentation was conjunctivitis seen in six patients. All MRSA isolates were sensitive to chloramphenicol. Ofloxacin resistance was observed in all isolates from patients over the age of 50 years. All patients had an underlying history of either an ocular surface disease, malignancy, or a debilitating medical illness.
MRSA is as yet an infrequent cause of external ocular infections. Patients typically have underlying ocular risk factors and/or are medically debilitated. Different strains infect young and old age groups with characteristic antimicrobial sensitivity. This study highlights the need for more work to establish the role of MRSA commensals and ocular infections.
确定英国一家眼科医院中耐甲氧西林金黄色葡萄球菌（MRSA）引起的眼部外部感染的患病率和临床特征。
对44个月期间经培养证实患有眼部外部葡萄球菌感染的患者病历进行回顾性分析。
金黄色葡萄球菌共引起548例眼部外部感染。其中，17例（3%）MRSA呈阳性。最常见的表现是6例患者出现结膜炎。所有MRSA分离株对氯霉素敏感。50岁以上患者的所有分离株均观察到对氧氟沙星耐药。所有患者都有眼表疾病、恶性肿瘤或衰弱性内科疾病的潜在病史。
MRSA目前仍是眼部外部感染的罕见病因。患者通常有潜在的眼部危险因素和/或身体衰弱。不同菌株感染年轻人和老年人，具有特征性的抗菌敏感性。本研究强调需要开展更多工作来确定MRSA共生菌和眼部感染的作用。
