Tsai L Y, Tsai S M, Horng N C
School of Technology for Medical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1991 Nov;7(11):550-5.
To study the influences of anticoagulants and sex-related variation on antioxidants, such as vitamins A and E, beta-carotene, and uric acid; and lipid peroxides such as malondialdehyde (MDA), we collected samples from 43 human subjects for research. In this study, it was found that: There were no differences of vitamin E and MDA concentrations and the ratio for tocopherol/total lipids among plasma from liquid EDTA(K3) blood and lithium heparin, or serum (p greater than 0.05). Nevertheless, plasma from liquid EDTA(K3) blood had significantly lower vitamin A. beta-carotene, uric acid, total cholesterol, triglyceride, and total lipids concentrations than did serum or plasma from blood treated with lithium heparin (p less than 0.01). The possible mechanism which reduced the above analytes was either EDTA-induced deterioration or oxidation. In sex-related variation study, sex differences in the plasma levels of vitamins A and E were insignificant (p greater than 0.05). Higher levels of plasma beta-carotene values were found in females (p less than 0.01); whereas, higher levels of plasma uric acid and MDA concentrations were found in males (p less than 0.01).
为研究抗凝剂和性别相关差异对维生素A、维生素E、β-胡萝卜素和尿酸等抗氧化剂以及丙二醛（MDA）等脂质过氧化物的影响，我们收集了43名人类受试者的样本进行研究。在本研究中，发现：液态乙二胺四乙酸（K3）抗凝血血浆、肝素锂抗凝血血浆和血清中的维生素E浓度、MDA浓度以及生育酚/总脂质的比例均无差异（p>0.05）。然而，液态乙二胺四乙酸（K3）抗凝血血浆中的维生素A、β-胡萝卜素、尿酸、总胆固醇、甘油三酯和总脂质浓度显著低于肝素锂抗凝血血浆或血清（p<0.01）。导致上述分析物含量降低的可能机制是乙二胺四乙酸诱导的变质或氧化。在性别相关差异研究中，血浆中维生素A和维生素E水平的性别差异不显著（p>0.05）。女性的血浆β-胡萝卜素水平较高（p<0.01）；而男性的血浆尿酸和MDA浓度较高（p<0.01）。
