Koda Mariusz, Sulkowska Mariola, Kanczuga-Koda Luiza, Surmacz Eva, Sulkowski Stanislaw
Department of Pathology, Medical University of Bialystok, Bialystok, Poland.
J Clin Pathol. 2007 Aug;60(8):902-6. doi: 10.1136/jcp.2006.041004.
Leptin is an adipocyte-derived neurohormone, high levels of which are found in obese individuals. Leptin controls energy expenditure, acting in the brain, and regulates different processes in peripheral organs. Recent studies have suggested that leptin may be involved in cancer development and progression.
To analyse leptin expression in human colorectal cancer as well as in colorectal mucosa and colorectal adenomas.
Leptin expression was assessed by immunohistochemistry in 166 colorectal cancers, 101 samples of colorectal mucosa and 41 adenomas. Leptin concentration in colorectal cancer was correlated with selected clinicopathological features.
Immunoreactivity for leptin was observed in 51.2% (85/166) of primary colorectal cancers. In adenomas leptin expression was observed in 14.6% (6/41) of studied cases. In normal mucosa, leptin was present at low levels, except in tumour bordering areas where its concentration appeared to reflect levels in the adjacent cancer tissue. Leptin expression in colorectal cancer significantly correlated with tumour G2 grade (p = 0.002) as well as with histological type (adenocarcinoma) of tumours (p = 0.044).
Results indicate that leptin is overexpressed in human colorectal cancer, which suggests that the hormone might contribute to colorectal cancer development and progression.
瘦素是一种由脂肪细胞产生的神经激素，肥胖个体中瘦素水平较高。瘦素控制能量消耗，作用于大脑，并调节外周器官的不同过程。最近的研究表明，瘦素可能参与癌症的发生和发展。
分析瘦素在人大肠癌、大肠黏膜及大肠腺瘤中的表达情况。
采用免疫组织化学方法检测166例大肠癌、101例大肠黏膜样本及41例腺瘤中瘦素的表达。将大肠癌中瘦素浓度与选定的临床病理特征进行相关性分析。
在51.2%（85/166）的原发性大肠癌中观察到瘦素免疫反应性。在腺瘤中，14.6%（6/41）的研究病例中观察到瘦素表达。在正常黏膜中，瘦素水平较低，除了肿瘤边缘区域，其浓度似乎反映了相邻癌组织中的水平。大肠癌中瘦素表达与肿瘤G2分级（p = 0.002）以及肿瘤组织学类型（腺癌）显著相关（p = 0.044）。
结果表明瘦素在人大肠癌中过度表达，这表明该激素可能促进大肠癌的发生和发展。
