Martin A O, Madsen E L, Dyer A R, White L, Bouck N P, Sabbagha R E, Hermanoff M, Chen J M, Ludtke L J
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois.
J Ultrasound Med. 1991 Dec;10(12):665-70. doi: 10.7863/jum.1991.10.12.665.
Lymphocyte and lymphoblastoid cells were exposed in vitro to diagnostic levels of ultrasonic beams delivered by a Hewlett-Packard CE 30001 and a GE system with a 5 MHz linear transducer for 20 sec, 1 min, 5 min, and 20 min. Temperature and cavitation effects were controlled and there were matched sham exposures. The synergistic effects of theophylline with ultrasonography also were investigated. Small increases in sister chromatid exchange levels were observed after ultrasonic exposure, but increases were so small as to be unlikely to have clinical relevance. Theophylline was found to have no effect and ultrasonography had no effect on cell viability.
将淋巴细胞和淋巴母细胞在体外暴露于由惠普CE 30001和配备5兆赫线性换能器的通用电气系统发出的诊断级超声波束下20秒、1分钟、5分钟和20分钟。控制了温度和空化效应，并进行了匹配的假暴露。还研究了茶碱与超声检查的协同效应。超声暴露后观察到姐妹染色单体交换水平有小幅增加，但增加幅度很小，不太可能具有临床相关性。发现茶碱没有作用，超声检查对细胞活力也没有影响。
