Miyakawa H, Matsumoto K, Matsumoto S, Mori M, Yoshitake S, Noguchi T, Taniguchi K, Honda N
Department of Anesthesiology, Medical College of Oita.
Masui. 1991 Oct;40(10):1503-6.
Shivering is one of the common complications after general anesthesia. It increases metabolic rate markedly and may cause myocardial ischemia in patients with decreased cardiopulmonary function. We investigated, therefore, the effects of three drugs (pethidine, magnesium sulfate and droperidol) on shivering in 30 patients under enflurane anesthesia. The patients were of ASA class I or II physical status and had no cardiovascular or respiratory disease. For post-anesthesia shivering, every patient was administered with pethidine 0.5 mg.kg-1, MgSO4 30 mg.kg-1 or droperidol 0.15 mg.kg-1. Their VO2 and VCO2 were measured for 5 minutes during shivering and 15 minutes after drug administration. We also evaluated the therapeutic efficacy of each drug for the treatment of shivering by examining VO2 and VCO2 before and after drug administration. With pethidine and MgSO4, both VO2 and VCO2 decreased significantly after each drug administration. With pethidine, VO2 and VCO2 decreased significantly more than that in MgSO4 (P less than 0.01 vs P less than 0.05). But with droperidol, there was no significant change. These results suggest that pethidine is most effective followed by MgSO4.
寒战是全身麻醉后常见的并发症之一。它会显著提高代谢率，对于心肺功能下降的患者可能会导致心肌缺血。因此，我们研究了三种药物（哌替啶、硫酸镁和氟哌利多）对30例恩氟烷麻醉患者寒战的影响。这些患者的ASA身体状况分级为I或II级，且无心血管或呼吸系统疾病。对于麻醉后寒战，每位患者分别给予哌替啶0.5mg·kg-1、硫酸镁30mg·kg-1或氟哌利多0.15mg·kg-1。在寒战期间测量5分钟以及给药后15分钟测量他们的耗氧量（VO2）和二氧化碳排出量（VCO2）。我们还通过检查给药前后的VO2和VCO2来评估每种药物治疗寒战的疗效。使用哌替啶和硫酸镁时，每种药物给药后VO2和VCO2均显著下降。使用哌替啶时，VO2和VCO2下降幅度明显大于硫酸镁（P<0.01对比P<0.05）。但使用氟哌利多时，没有显著变化。这些结果表明哌替啶最有效，其次是硫酸镁。
