Sugihara K
Department of Anesthesiology, University of Hirosaki School of Medicine.
Masui. 1991 Jan;40(1):49-60.
Effect of intramuscular administration of pethidine on cardiovascular and endocrine functions were studied as judged by cardiac variables and plasma hormone levels in dogs under 1% enflurane anesthesia. Twenty-four mongrel dogs were divided into three groups. Seven dogs receiving physiological saline only served as the control group. Pethidine 2 mg.kg-1 was given to each of nine dogs (2 mg.kg-1 group), and in the remaining eight dogs 6 mg.kg-1 of the drug was administered (6 mg.kg-1 group). Swan-Ganz catheter was used for measurement of cardiac variables such as central venous pressure, cardiac output, pulmonary capillary wedge pressure and etc. In the 6 mg.kg-1 group, mean arterial pressure, heart rate and cardiac index decreased significantly, but no significant changes in cardiac variables were observed in the 2 mg.kg-1 group. Plasma levels of cortisol and ACTH decreased significantly in the 6 mg.kg-1 group and tended to decrease in the 2 mg.kg-1 group. No significant changes were observed in plasma levels of catecholamines, aldosterone, renin activity, antidiuretic hormone and insulin in both groups. These findings suggest that in dogs under 1% enflurane anesthesia intramuscular administration of pethidine 6 mg.kg-1 would depress cardiac functions and intramuscular administration of pethidine more than 2 mg.kg-1 would also depress adrenocortical function.
在1%安氟醚麻醉下，通过犬的心脏变量和血浆激素水平来研究肌肉注射哌替啶对心血管和内分泌功能的影响。24只杂种犬被分为三组。7只仅接受生理盐水注射的犬作为对照组。9只犬每只给予2mg·kg-1哌替啶（2mg·kg-1组），其余8只犬给予6mg·kg-1该药（6mg·kg-1组）。使用Swan-Ganz导管测量中心静脉压、心输出量、肺毛细血管楔压等心脏变量。在6mg·kg-1组中，平均动脉压、心率和心脏指数显著下降，但在2mg·kg-1组中未观察到心脏变量有显著变化。6mg·kg-1组中皮质醇和促肾上腺皮质激素的血浆水平显著下降，2mg·kg-1组有下降趋势。两组中儿茶酚胺、醛固酮、肾素活性、抗利尿激素和胰岛素的血浆水平均未观察到显著变化。这些发现表明，在1%安氟醚麻醉的犬中，肌肉注射6mg·kg-1哌替啶会抑制心脏功能，肌肉注射超过2mg·kg-1的哌替啶也会抑制肾上腺皮质功能。
