Khan T, Ahmad M
Research Institute of Pharmaceutical Sciences, University of Karachi, Pakistan.
Pharmazie. 2007 Jun;62(6):476-7.
The crude extract and subsequent fractions from the aerial parts of P. emodi were studied for their effects on the isolated rabbit jejunum. The crude extract displayed significant spasmolytic activity in a dose-dependent manner and inhibited the spontaneous motility of the rabbit jejunum by 76% at 5 mg/mL concentration. The ethyl acetate and chloroform fractions exhibited excellent spasmolytic activities and were more potent than the native crude extract. The n-butanol fraction showed a very low inhibitory activity in this bioassay. The water soluble fraction, unlike crude extract, displayed an overall spasmogenic activity. The crude extracts also effectively reduced the acetylcholine induced contractions in the isolated rabbit jejunum.
对喜马拉雅旌节花地上部分的粗提物及其后续馏分对离体兔空肠的作用进行了研究。粗提物呈剂量依赖性地表现出显著的解痉活性，在浓度为5mg/mL时可抑制兔空肠的自发运动达76%。乙酸乙酯和氯仿馏分表现出优异的解痉活性，且比天然粗提物更有效。正丁醇馏分在该生物测定中显示出非常低的抑制活性。与粗提物不同，水溶性馏分表现出总体的致痉活性。粗提物还能有效降低离体兔空肠中乙酰胆碱诱导的收缩。
