Williams E L, Endean A L, Edwards C J
Rheumatology Department, Southampton University Hospitals NHS Trust, Southampton, UK.
Lupus. 2007;16(6):444-6. doi: 10.1177/0961203307077670.
The authors present a case of myocardial infarction in a 26-year-old man with antiphospholipid syndrome (APS) and a history of recent cocaine use. His only traditional cardiovascular risk was that he smoked. The authors propose that his cocaine use and APS brought about a potentially catastrophic cardiac event despite therapeutic anticoagulation. This was supported by the finding of normal coronary arteries on angiography despite both a significant regional wall motion abnormality on echocardiography and a significant rise in Troponin I. This case suggests the presence of a synergistic effect between cocaine and antiphospholipid antibodies.
作者报告了一例26岁男性心肌梗死病例，该患者患有抗磷脂综合征（APS）且近期有使用可卡因史。他唯一的传统心血管风险因素是吸烟。作者提出，尽管进行了治疗性抗凝，但他使用可卡因和患有APS引发了一场潜在的灾难性心脏事件。血管造影显示冠状动脉正常，而超声心动图显示有明显的局部室壁运动异常且肌钙蛋白I显著升高，这些发现支持了上述观点。该病例提示可卡因与抗磷脂抗体之间存在协同效应。
