Das J, Mandal A C
Department of Dermatology &STD, Gauhati Medical College, Guwahatt-781 032, India.
Indian J Dermatol Venereol Leprol. 2001 Sep-Oct;67(5):238-9.
Sixty cases of drug eruptions were observed during the period of one year. The incidence of drug eruption was 0.47% amongst all Dermatology O.P.D. attendances. Male to female ratio was 7:3. The highest number of cases were seen in the age group of 21-30 years. Fixed drug eruptions were the most frequent (58.3%), followed by urticaria and angioedema (20%). The drug sulphonamides (including co-trimoxazole) accounted for the highest number of eruptions (35%). The other drugs which were responsible for the eruptions, in order of frequency, were oxyphenbutazone, ampicillin, analgin, penicillin, tetracycline, ibuprofen, paracetamol, phenylbutazone, acetaminophen and phenobarbitone. The causative drug (s) were confirmed by provocation tests in 42 (70%) cases.
在一年期间观察到60例药疹病例。在所有皮肤科门诊就诊患者中，药疹的发病率为0.47%。男女比例为7:3。21至30岁年龄组的病例数最多。固定性药疹最为常见（58.3%），其次是荨麻疹和血管性水肿（20%）。磺胺类药物（包括复方新诺明）引发的皮疹数量最多（35%）。按频率排序，其他引发药疹的药物依次为羟布宗、氨苄西林、安乃近、青霉素、四环素、布洛芬、对乙酰氨基酚、保泰松、醋氨酚和苯巴比妥。42例（70%）病例通过激发试验确诊了致病药物。
