[双硫腙糖尿病中胰岛β细胞的超微结构及其二乙基二硫代氨基甲酸钠预防作用]
[The ultrastructure of pancreatic beta cells in dithizone diabetes and its prevention by sodium diethyldithiocarbamate].
作者信息
Meĭramov G G, Trukhanov N I
出版信息
Probl Endokrinol (Mosk). 1975 Nov-Dec;21(6):92-5.
PMID:176649
Abstract
Administration of a nondiabetogenic complex-former-sodium diethyldithiocarbamate (SDEDTC) to rabbits prevented the appearance in beta-cells of the insular apparatus of histological and ultramicroscopic changes with the subsequent administration of a potent diabetogenic agent-ditisone. SDEDTC blocked the insular zinc and prevented ditisone from forming in the islets a complex with this metal producing a destructive action of beta-cells.
摘要
给兔子施用一种非致糖尿病的络合剂——二乙基二硫代氨基甲酸钠（SDEDTC），可防止在随后施用强效致糖尿病剂——地塞米松后，胰岛装置的β细胞出现组织学和超微结构变化。SDEDTC阻断了胰岛锌，并防止地塞米松在胰岛中与这种金属形成复合物，从而对β细胞产生破坏作用。
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