Lazaris J A, Bavelsky Z E
Endocrinol Exp. 1984 Sep;18(3):157-67.
Diabetogenic action of dithisone was investigated in a total of 368 adult rabbits and 53 young animals between 10 h and 31 days of age. The diabetes was found in 95% of animals injected with dithisone and various forms of this disease were observed: 1. long-term diabetes without any signs of normalization of glycemia; 2. diabetes with periodical remissions; 3. several cases with a definite remission. The diabetes did not appear in young animals during certain periods of life in which the concentration of zinc in pancreatic islets was very low. It was possible to prevent the development of this disease by the administration of some compounds containing sulfhydryl or imidazole groups (cysteine, SH-glutathione, dimercaptopropanol (BAL), unithiol (sodium 2,3-dimercaptopropansulfonate), (histidine) and the diabetes also did not appear in such animals in which a majority of zinc was removed by glybenclamide. From these observations it was concluded that the development of diabetes after dithisone depends on the formation of dithisone complex with zinc in beta-cells.
对总共368只成年兔以及53只10小时至31日龄的幼兔进行了二噻松致糖尿病作用的研究。在注射二噻松的动物中，95%出现了糖尿病，且观察到了这种疾病的多种形式：1. 长期糖尿病，血糖无任何正常化迹象；2. 周期性缓解的糖尿病；3. 几例有明确缓解的病例。在胰岛锌浓度非常低的幼兔生命中的某些时期，未出现糖尿病。通过给予一些含巯基或咪唑基团的化合物（半胱氨酸、巯基谷胱甘肽、二巯丙醇（BAL）、二巯丙磺钠（二巯基丙磺酸钠）、（组氨酸），有可能预防这种疾病的发生，并且在大部分锌被格列本脲去除的动物中也未出现糖尿病。从这些观察结果得出结论，二噻松后糖尿病的发生取决于二噻松与β细胞中的锌形成复合物。
