Lazaris J A, Babelskyi F J
Endocrinol Exp. 1979 Mar;13(1):39-51.
Diethyldithiocarbamate sodium (DDC)--a compound forming complexes with metal ions-did not change the structure of endocrine pancreas and did not affect the glycemia after the repeated administration of a dose of 250 mg kg-1 while a single dose of 500 or 1000 mg kg-1 increased the glycemia for 2 to 4 h in most of rabbits tested. DDC injected in similar doses prevented a diabetogenic action of dithisone and of a number of 8-oxichinoline derivatives. This effect appeared very rapidly and persisted for several hours being dependent on a dose of DDC and on the interval between its administration and the injection of diabetogenic compounds. It was concluded that DDC forms stable complexes with zinc ions in pancreatic beta-cells which appear to be resistant towards the action of diabetogenic compounds directed selectively to the blocking of zinc ions too and thus to the development of experimental diabetes.
二乙基二硫代氨基甲酸钠（DDC）——一种能与金属离子形成络合物的化合物——在重复给予250毫克/千克剂量时，不会改变内分泌胰腺的结构，也不会影响血糖水平；而单次给予500或1000毫克/千克剂量时，在大多数受试兔子中，血糖会在2至4小时内升高。以类似剂量注射的DDC可预防二苯硫腙和多种8-羟基喹啉衍生物的致糖尿病作用。这种作用出现得非常迅速，并持续数小时，这取决于DDC的剂量以及其给药与注射致糖尿病化合物之间的间隔时间。得出的结论是，DDC在胰腺β细胞中与锌离子形成稳定的络合物，这些络合物似乎对选择性针对锌离子阻断作用的致糖尿病化合物的作用具有抗性，从而对实验性糖尿病的发展具有抗性。
