Yang Ying, Zhou Libin, Gu Yuanjun, Zhang Yibo, Tang Jingfeng, Li Fengying, Shang Wenbin, Jiang Boren, Yue Xiaohua, Chen Mingdao
Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, 197 Ruijin Road II, Shanghai 200025, China.
Br J Nutr. 2007 Oct;98(4):720-6. doi: 10.1017/S0007114507750870. Epub 2007 Aug 1.
The improved effects of dietary chickpeas on visceral adiposity, dyslipidaemia and insulin resistance were examined. Rats were fed a normal-fat diet (NFD), a high-fat diet (HFD) or a high-fat plus chickpea diet (HFD+CP) for 8 months. The epididymal fat pad weight v. total body weight of rats was higher in the HFD group (0.032 (sd 0.0042) g/g) than in the NFD group (0.015 (sd 0.0064) g/g) and smaller in the HFD+CP group (0.023 (sd 0.0072) g/g) compared with the HFD group (P < 0.05). Chickpea treatment also induced a favourable plasma lipid profile reflecting decreased TAG, LDL-cholesterol (LDL-C) and LDL-C:HDL-cholesterol levels (P < 0.05). HFD-fed rats had higher TAG concentration in muscle and liver, whereas the addition of chickpeas to the HFD drastically lowered TAG concentration (muscle, 39 %; liver, 23 %). The activities of lipoprotein lipase (LPL) in epididymal adipose tissue and hepatic TAG lipase in liver recorded a 40 and 23 % increase respectively in HFD rats compared with those in NFD rats; dietary chickpeas completely normalised the levels. Furthermore, chickpea-treated obese rats also showed a markedly lower leptin and LPL mRNA content in epididymal adipose tissue. An insulin tolerance test, oral glucose tolerance test and insulin-releasing test showed that chickpeas significantly improved insulin resistance, and prevented postprandial hyperglycaemia and hyperinsulinaemia induced by the chronic HFD. The present findings provide a rational basis for the consumption of chickpeas as a functional food ingredient, which may be beneficial for correcting dyslipidaemia and preventing diabetes.
研究了食用鹰嘴豆对内脏脂肪过多、血脂异常和胰岛素抵抗的改善作用。将大鼠分别喂食正常脂肪饮食（NFD）、高脂饮食（HFD）或高脂加鹰嘴豆饮食（HFD+CP）8个月。与NFD组（0.015（标准差0.0064）g/g）相比，HFD组大鼠附睾脂肪垫重量与总体重之比更高（0.032（标准差0.0042）g/g），而HFD+CP组（0.023（标准差0.0072）g/g）相比HFD组更小（P<0.05）。鹰嘴豆处理还诱导了有利的血脂谱，表现为甘油三酯（TAG）、低密度脂蛋白胆固醇（LDL-C）和LDL-C：高密度脂蛋白胆固醇水平降低（P<0.05）。喂食HFD的大鼠肌肉和肝脏中的TAG浓度较高，而在HFD中添加鹰嘴豆可显著降低TAG浓度（肌肉中降低39%；肝脏中降低23%）。与NFD大鼠相比，HFD大鼠附睾脂肪组织中的脂蛋白脂肪酶（LPL）活性和肝脏中的肝TAG脂肪酶活性分别增加了40%和23%；饮食中的鹰嘴豆使这些水平完全恢复正常。此外，用鹰嘴豆处理的肥胖大鼠附睾脂肪组织中的瘦素和LPL mRNA含量也显著降低。胰岛素耐量试验、口服葡萄糖耐量试验和胰岛素释放试验表明，鹰嘴豆显著改善了胰岛素抵抗，并预防了慢性HFD诱导的餐后高血糖和高胰岛素血症。本研究结果为将鹰嘴豆作为功能性食品成分食用提供了合理依据，这可能有助于纠正血脂异常和预防糖尿病。
