Mohsin Saima Naz, Saleem Faiza, Humayun Ayesha, Tanweer Afifa, Muddassir Ambreen
NIH, HRI, Research Center NHRC, Shaikh Zayed Post Graduate Medical Institute, Lahore, Pakistan.
Department of Biotechnology, Lahore College for Women University, Lahore, Pakistan.
Dose Response. 2023 Sep 10;21(3):15593258231200527. doi: 10.1177/15593258231200527. eCollection 2023 Jul-Sep.
Apart from advances in pharmaceutical antidiabetic agents, efforts are being made toward hypoglycemic agents derived from natural sources. Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antidiabetic, and anti-hypertriglyceridemic agent. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and solvent extraction. These chemicals help in decreasing insulin resistance and can act against hyperglycemia and dyslipidemia, inflammation and oxidative stress, obesity, overweight, and abnormal glycation of proteins. Cinnamon has shown to improve all of these conditions in , animal, and/or human studies. However, the mechanism of action of active ingredients found in cinnamon remains unclear. The current review presents the outstanding ability of cinnamon derivatives to control diabetes by various pathways modulating insulin release and insulin receptor signaling. It was also found that the type and dosage of cinnamon as well as subject characteristics including drug interactions are likely to affect the response to cinnamon. Future research directions based on this review include the synergistic usage of various cinnamon derivatives in managing and/or preventing diabetes and possible other relevant chronic diseases.
除了药物抗糖尿病药物的进展外，人们还在努力研发天然来源的降血糖药物。据报道，肉桂对人体健康有显著益处，特别是作为一种抗炎、抗糖尿病和抗高甘油三酯药物。肉桂中的植物化学物质可以通过蒸馏和溶剂萃取从植物的不同部位提取。这些化学物质有助于降低胰岛素抵抗，并可对抗高血糖和血脂异常、炎症和氧化应激、肥胖、超重以及蛋白质的异常糖化。在动物和/或人体研究中，肉桂已显示出能改善所有这些状况。然而，肉桂中活性成分的作用机制仍不清楚。本综述介绍了肉桂衍生物通过调节胰岛素释放和胰岛素受体信号传导的各种途径控制糖尿病的卓越能力。还发现肉桂的类型和剂量以及包括药物相互作用在内的受试者特征可能会影响对肉桂的反应。基于本综述的未来研究方向包括各种肉桂衍生物在管理和/或预防糖尿病以及可能的其他相关慢性病中的协同使用。
